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Key Technologies 2017-03-22T08:36:00+00:00

Key Technologies

The Adroit Science laboratory is set up with a mix of modern state-of-the art instrumentation together with internally designed innovative equipment. In the foreground of this picture an Adroit Science innovation is shown, i.e., a unique instrument for multiple and novel crystallisation of compounds. The technology can be used for crystallisation of “hard-to-crystallise” compounds, for making single crystals as well as for salt and polymorph screening.

Adroit Science Key Technologies

Key Technologies

XRPD – X-Ray Powder diffraction (high resolution). Crystallinity, polymorph identification/purity, amorphous content, phase quantification, structural understanding etc. Including non-ambient analysis with temperatures from RT to 120 °C and RH from 0 to 95% RH at ambient temperature.

IR – Infrared spectroscopy. Identification of compounds, quantification of content and characterization of interactions in mixtures.

Raman spectroscopy/microscopy – Polymorph identity and content, amorphous content, distribution of formulation components.

DSC – Differential Scanning Calorimetry, including both temperature modulation and fast scan ability. Evaluation of a sample’s thermal behavior, e.g. melting temperature, glass transition temperature, crystallization temperature, solid state transitions etc.

TGA – Thermal Gravimetric Analyze. Determination of change in weight as a response to change in temperature like quantification of residual solvents, evaporation temperature and kinetics for instance.

GVS – Gravimetric Vapor Sorption. Evaluation of hygroscopicity, water sorption behavior at different relative humidity’s, deliquescence, hydrate characterization, amorphicity etc.

TAM – Thermal Activity Monitor (microcalorimetry). Evaluation of any type of biological, chemical and physical process by detection and quantification of the related heat flow (exothermic or endothermic). This instrument is sensitive enough to detect e.g. peptide aggregation processes or chemical degradation and can be used as a very rapid method to predict physical/chemical stability of a formulation.

BET – Brunauer, Emmett, Teller. Determination of specific surface area on powders (using N2 adsorption at the temperature of liquid nitrogen). Determination of micro pore volume and meso pore distribution of solid samples.

Pycnometer – Helium based instrument used for the determination of absolute density of solid samples and powders.

LALLS – Low Angle Laser Light Scattering. Determination of particle size distribution for powders or suspensions using laser diffraction.

NMR – Nuclear Magnetic Resonance. Identification of molecular structure and/or purity. Performed in collaboration with a partner.

IR – Infrared spectroscopy. Identification of compounds, quantification of content and characterization of interactions in mixtures.

SEM & EDS-SEM – Scanning Electron Microscopy. High magnification microscopy with potential for simultaneous elemental analysis using EDS (Energy Dispersive Spectroscopy).

LM – Light Microscopy. Optical microscope equipped with crossed polarized filters and camera functionality. Also available in inversed (from bottom) mode.

SXRD/Synchrotron – Single crystal X-Ray Diffraction. Solving of crystal structure for solids based on either SXRD or Synchrotron (for very small crystals) or even from Powders in difficult cases. Performed in collaboration with partnercompany.

Micronisation – Particle size reduction technology using spiral jet mill (fluidized energy mill) is a very efficient way to obtain even micron sized particles in a continuous process. Offered as a small scale (a few gram up to a few 100 gram) support.

Conditioning (restoration of crystallinity) – Adroit Science provide a unique advanced and well-proven technology for restoration of surface amorphicity induced by e.g. micronisation. The technology can be provided in any scale relevant for manufacturing of powders for inhalation.

Crystallizer – In-house developed, solvent based, crystallization technology where multiple and simultaneous combinations of parameters are possible in each experiment. Applicable for crystallization of “difficult” substances, single crystal growth, salt and polymorph investigations production of seeds, screening of crystallization parameters and much more.