Amorphous material has quite different properties than what the crystalline phase(s) exhibit. Occasionally, the amorphous state is the preferred one due to inherent features like e.g. increased solubility. On the other hand, as being in a metastable state the material will normally be significantly “more reactive” and consequently have many inherent potential issues. Normally, the crystalline state will be the preferred option, at least from a development perspective, and it is then of utmost importance to avoid any amorphous content. If located on the surface even tiny amounts of amorphicity may dramatically alter key properties like processing behavior or degradation tendency. Consequently it is crucial to have perfect control over the existence, and/or the introduction, of even minute amounts of amorphicity in a given substance or formulation so that suboptimal properties can be avoided.
Adroit Science coworkers have an extensive track record from e.g. drug administration using dry powder inhalation where the obtained powder properties originated from 3 µm particles are the key to success. Hence, the ability for detection, quantification and even characterization of amorphous contents on extremely low levels (in some cases down to 0.1% for a pure substance,) both for single compounds and in formulations is imperative. Consequently, we have developed a comprehensive experience of using and elaborating different technologies suitable to address various challenges. We can offer innovative and relevant state of the art methodologies, for identification and quantification, supporting an optimal project delivery.